Washington: While the likes of Pamela Anderson advise fans to turn veggie to spice up their sex lives, a recent study asks people to eat vegetables to inhibit the occurrence of hereditary colon cancer.
A new study at Rutgers shows that certain vegetables including broccoli and cauliflower, have natural ingredients that may reduce the risk of developing hereditary cancers, those arising from one's genetic makeup.
A research team led by Rutgers' Ah-Ng Tony Kong has revealed that these widely consumed cruciferous vegetables are abundant in sulforaphane (SFN), a compound that had previously been shown to inhibit some cancers in rodents induced by carcinogens, substances or agents external to the body.
The American Cancer Society estimates that more than two-thirds of cancer may be prevented through lifestyle modification, and nearly one-third of these cancer occurrences can be attributed to diet alone.
"Our research has substantiated the connection between diet and cancer prevention, and it is now clear that the expression of cancer-related genes can be influenced by chemopreventive compounds in the things we eat," said Kong, a professor of pharmaceutics in the Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey.
Chemopreventive properties are those that prevent, stop or reverse the development of cancer.
In a study published online in the journal Carcinogenesis, Kong and his colleagues used a mouse model for human colon cancer to demonstrate the chemopreventive power of SFN and explain how it works to thwart cancer at the biomolecular level.
"Our results clearly demonstrated that those mice fed with an SFN-supplemented diet developed significantly fewer and smaller tumors," Kong said.
"Our results showed that SFN produced its cancer preventive effects in the mice by inducing apoptosis (programmed cell death) and inhibiting proliferation of the tumors; however, it was not clear what mechanism SFN employs to accomplish this," Kong said.
Using biomarkers (indicator molecules) associated with apoptosis and proliferation, Kong's team found that SFN suppressed certain enzymes or kinases that are highly expressed both in the mice and in patients with colon cancer.
The researchers concluded that this enzymatic suppression activity is the likely basis for the chemopreventive effects of SFN.
"Our study corroborates the notion that SFN has chemopreventive activity. Based on these findings, we feel SFN should be evaluated clinically for its chemopreventive potential in human patients with Apc related colon cancers," Kong said.
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