She went down 4-6, 4-6 to the eighth seeded Flavia Pennetta.
Tokyo: Second seed Sania Mirza crashed out of the $175,000 Japan Open in Tokyo after a straight set loss to Italian Flavia Pennetta in the quarter-finals on Thursday.
The Indian went down 4-6, 4-6 to the eighth seeded Italian in her first tournament after recovering from a wrist injury.
Pennetta will now take on fifth seed Virgini Razzano of France in the semi-finals.
Razzano beat her compatriot Camille Pin easily 6-2, 6-2 in the other quarter-final match.
Sania's doubles campaign in the WTA tier III event also came to an end after she and her American partner Christina Fusano gave a walkover to the second seeded Chinese pair of Tiantian Sun and Zi Yan in the quarter-finals.
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